Quantitative assessment of multiple pathogen exposure and immune dynamics at scale.

ABSTRACT:

Importance

Serology reveals exposure to pathogens, as well as the state of autoimmune and other clinical conditions. It is used to evaluate individuals and their histories and as a public health tool to track epidemics. Employing a variety of formats, studies nearly always perform serology by testing response to only one or a few antigens. However, clinical outcomes of new infections also depend on which previous infections may have occurred. We developed a high-throughput serology method that evaluates responses to hundreds of antigens simultaneously. It can be used to evaluate thousands of samples at a time and provide a quantitative readout. This tool will enable doctors to monitor which pathogens an individual has been exposed to and how that changes in the future. Moreover, pu

SUBMITTER: Song L 

PROVIDER: S-EPMC10783028 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature