Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models.
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ABSTRACT: Importance
There is a strong need to find novel treatment options against urinary tract infections associated with antimicrobial resistance. This study evaluates two atypical tetracyclines, namely chelocardin (CHD) and amidochelocardin (CDCHD), with respect to their pharmacokinetics and pharmacodynamics. We show CHD and CDCHD are cleared at high concentrations in mouse urine. Especially, CDCHD is highly effective in an ascending urinary tract infection model, suggesting further preclinical evaluation.
SUBMITTER: Rox K
PROVIDER: S-EPMC10783034 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models.
Rox Katharina K Jansen Rolf R Lukežič Tadeja T Greweling-Pils Marina M Herrmann Jennifer J Miethke Marcus M Hüttel Stephan S Hennessen Fabienne F Abou Fayad Antoine A Holzhausen Cornelia C Lundberg Carina Vingsbo CV Teague Joanne J Sudarman Enge E Bülter Lisa L Hesterkamp Thomas T Stadler Marc M Brönstrup Mark M Müller Rolf R
Microbiology spectrum 20231204 1
<h4>Importance</h4>There is a strong need to find novel treatment options against urinary tract infections associated with antimicrobial resistance. This study evaluates two atypical tetracyclines, namely chelocardin (CHD) and amidochelocardin (CDCHD), with respect to their pharmacokinetics and pharmacodynamics. We show CHD and CDCHD are cleared at high concentrations in mouse urine. Especially, CDCHD is highly effective in an ascending urinary tract infection model, suggesting further preclinic ...[more]
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