Phasevarions in Haemophilus influenzae biogroup aegyptius control expression of multiple proteins.

ABSTRACT:

Importance

Haemophilus influenzae biogroup aegyptius is a human-adapted pathogen and the causative agent of Brazilian purpuric fever (BPF), an invasive disease with high mortality, that sporadically manifests in children previously suffering conjunctivitis. Phase variation is a rapid and reversible switching of gene expression found in many bacterial species, and typically associated with outer-membrane proteins. Phase variation of cytoplasmic DNA methyltransferases has been shown to play important roles in bacterial gene regulation and can act as epigenetic switches, regulating the expression of multiple genes as part of systems called phasevarions (phase-variable regulons). This study characterized two alleles of the ModA phasevarion present in H. influenzae

SUBMITTER: Tram G 

PROVIDER: S-EPMC10783040 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature