Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner.

ABSTRACT:

Importance

Activation of the host transcription factor TFEB helps mammalian cells adapt to stresses such as starvation and infection by upregulating lysosome, autophagy, and immuno-protective gene expression. Thus, TFEB is generally thought to protect host cells. However, it may also be that pathogenic bacteria like Salmonella orchestrate TFEB in a spatio-temporal manner to harness its functions to grow intracellularly. Indeed, the relationship between Salmonella and TFEB is controversial since some studies showed that Salmonella actively promotes TFEB, while others have observed that Salmonella degrades TFEB and that compounds that promote TFEB restrict bacterial growth. Our work provides a path to resolve these apparent discordant observations since we

SUBMITTER: Inpanathan S 

PROVIDER: S-EPMC10783059 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature