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Phosphoproteomic landscape of pseudorabies virus infection reveals multiple potential antiviral targets.

ABSTRACT:

Importance

Pseudorabies virus (PRV) is a kind of alpha herpesvirus that infects a wide range of animals and even human beings. Therefore, it is important to explore the mechanisms behind PRV replication and pathogenesis. By conducting a tandem mass tag-based phosphoproteome, this study revealed the phosphorylated proteins and cellular response pathways involved in PRV infection. Findings from this study shed light on the relationship between the phosphorylated cellular proteins and PRV infection, as well as guiding the discovery of targets for the development of antiviral compounds against PRV.

SUBMITTER: Bo Z

PROVIDER: S-EPMC10783065 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Phosphoproteomic landscape of pseudorabies virus infection reveals multiple potential antiviral targets.

Bo Zongyi Z Li Xiaojuan X Zhang Chengcheng C Guo Mengjiao M Cao Yongzhong Y Zhang Xiaorong X Wu Yantao Y

Microbiology spectrum 20231122 1

<h4>Importance</h4>Pseudorabies virus (PRV) is a kind of alpha herpesvirus that infects a wide range of animals and even human beings. Therefore, it is important to explore the mechanisms behind PRV replication and pathogenesis. By conducting a tandem mass tag-based phosphoproteome, this study revealed the phosphorylated proteins and cellular response pathways involved in PRV infection. Findings from this study shed light on the relationship between the phosphorylated cellular proteins and PRV i ...[more]

PMID: 37991362

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