Changes in lipid composition of host-derived extracellular vesicles following Salmonella infection.

ABSTRACT:

Importance

This study delves into the previously unexplored territory of extracellular vesicle (EV) cargo and composition, specifically focusing on lipid composition changes in EVs following Salmonella infection. EVs play crucial roles in intercellular communication, carrying a variety of biomolecules. Investigating how these EV cargo lipids change post-infection with Salmonella is significant for understanding the molecular mechanisms underlying lipid trafficking during infection. Given the impact of lipid composition on EV function, this research uncovers distinct differences in the lipid profiles of EVs at different time points post-infection and between infected and uninfected macrophages. This study identified lipids that are differentially abundant in EVs produc

SUBMITTER: Emerson LE 

PROVIDER: S-EPMC10783105 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature