Visceral adipose microbial and inflammatory signatures in metabolically healthy and unhealthy nonhuman primates.

ABSTRACT:

Objective

Obesity is a key risk factor for metabolic syndrome (MetS); however, >10% of lean individuals meet MetS criteria. Visceral adipose tissue (VAT) disproportionately contributes to inflammation and insulin resistance compared with subcutaneous fat depots. The primary aim of this study was to profile tissue microbiome components in VAT over a wide range of metabolic statuses in a highly clinically relevant model.

Methods

VAT was profiled from nonhuman primates that naturally demonstrate four distinct health phenotypes despite consuming a healthy diet, namely metabolically healthy lean and obese and metabolically unhealthy lean and obese.

Results

VAT biopsied from unhealthy lean and obese nonhuman primates demonstrated upregulation of immune signaling pathways, a

SUBMITTER: Ruggiero AD 

PROVIDER: S-EPMC10783165 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature