Role of oxidative stress in neurodegenerative disorders: a review of reactive oxygen species and prevention by antioxidants.

ABSTRACT: Neurological disorders include a variety of conditions, including Alzheimer's disease, motor neuron disease and Parkinson's disease, affecting longevity and quality of life, and their pathogenesis is associated with oxidative stress. Several of the chronic neurodegenerative pathologies of the CNS share some common features, such as oxidative stress, inflammation, synapse dysfunctions, protein misfolding and defective autophagia. Neuroinflammation can involve the activation of mast cells, contributing to oxidative stress, in addition to other sources of reactive oxygen species. Antioxidants can powerfully neutralize reactive oxygen species and free radicals, decreasing oxidative damage. Antioxidant genes, like the manganese superoxide dismutase enzyme, can undergo epigenetic changes that re

SUBMITTER: Houldsworth A 

PROVIDER: S-EPMC10783645 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature