The Impact of Recent Demography on Functional Genetic Variation in North African Human Groups.

ABSTRACT: The strategic location of North Africa has made the region the core of a wide range of human demographic events, including migrations, bottlenecks, and admixture processes. This has led to a complex and heterogeneous genetic and cultural landscape, which remains poorly studied compared to other world regions. Whole-exome sequencing is particularly relevant to determine the effects of these demographic events on current-day North Africans' genomes, since it allows to focus on those parts of the genome that are more likely to have direct biomedical consequences. Whole-exome sequencing can also be used to assess the effect of recent demography in functional genetic variation and the efficacy of natural selection, a long-lasting debate. In the present work, we use newly generated whole-exome s

SUBMITTER: Lucas-Sanchez M 

PROVIDER: S-EPMC10783648 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature