Neuronal tuning to threat exposure remains stable in the mouse prefrontal cortex over multiple days.

ABSTRACT: Intense threat elicits action in the form of active and passive coping. The medial prefrontal cortex (mPFC) executes top-level control over the selection of threat coping strategies, but the dynamics of mPFC activity upon continuing threat encounters remain unexplored. Here, we used 1-photon calcium imaging in mice to probe the activity of prefrontal pyramidal cells during repeated exposure to intense threat in a tail suspension (TS) paradigm. A subset of prefrontal neurons displayed selective activation during TS, which was stably maintained over days. During threat, neurons showed specific tuning to active or passive coping. These responses were unrelated to general motion tuning and persisted over days. Moreover, the neural manifold traversed by low-dimensional population activity remai

SUBMITTER: Sylte OC 

PROVIDER: S-EPMC10783789 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature