Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population.

ABSTRACT: The incidence and mortality of chronic kidney disease (CKD) are increasing globally. Studies have demonstrated the significance of genetic risk factors in the progression of CKD. Telomerase reverse transcriptase (TERT) may be implicated in the development of CKD. This study aimed to investigate the correlation between TERT gene variants and susceptibility to CKD in the Chinese population. A total of 507 patients with CKD and 510 healthy controls were recruited for this case-control study. Four candidate loci were identified using the MassARRAY platform. Logistic regression analysis was employed to assess the association between TERT gene variants and the risk of CKD. The false positive reporting probability (FPRP) method was utilized to evaluate the validity of statist

SUBMITTER: Su Y 

PROVIDER: S-EPMC10783823 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature