Hippocampal volume and resting-state functional connectivity on magnetic resonance imaging in patients with Parkinson and depression.

ABSTRACT:

Background

Recent structural and functional imaging studies of depression in Parkinson disease (DPD) have failed to reveal the relevant mechanism, and relatively few studies have been conducted on limbic systems such as the hippocampus. This study thus aimed to gain new insights into the pathogenesis of DPD by detecting the changes in the hippocampal structure and the resting-state functional connectivity (FC) of patients with DPD.

Methods

This study included 30 patients with DPD (DPD group), 30 patients with nondepressed Parkinson disease (NDPD; NDPD group), and 30 normal controls (NCs; NC group) with no significant age or gender differences with the DPD group. The Hamilton Depression Rating Scale (HAMD) and three-dimensional T1-weighted imaging and blood oxygen level-depen

SUBMITTER: Liang L 

PROVIDER: S-EPMC10784022 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature