U-fiber analysis: a toolbox for automated quantification of U-fibers and white matter hyperintensities.

ABSTRACT:

Background

Whether white matter hyperintensities (WMHs) involve U-fibers is of great value in understanding the different etiologies of cerebral white matter (WM) lesions. However, clinical practice currently relies only on the naked eye to determine whether WMHs are in the vicinity of U-fibers, and there is a lack of good neuroimaging tools to quantify WMHs and U-fibers.

Methods

Here, we developed a multimodal neuroimaging toolbox named U-fiber analysis (UFA) that can automatically extract WMHs and quantitatively characterize the volume and number of WMHs in different brain regions. In addition, we proposed an anatomically constrained U-fiber tracking scheme and quantitatively characterized the microstructure diffusion properties, fiber length, and number of U-fibers in dif

SUBMITTER: Zheng G 

PROVIDER: S-EPMC10784071 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature