Identification and validation of a disulfidptosis-related genes prognostic signature in lung adenocarcinoma.

ABSTRACT: Disulfidptosis, a newly revealed form of cell death, regulated by numerous genes that has been recently identified. The exact role of disulfidptosis in lung adenocarcinoma (LUAD) still uncertain. Objective of this study was to explore potential prognostic markers among disulfidptosis genes in LUAD. By combining transcriptomic information from Gene Expression Omnibus databases and The Cancer Genome Atlas, we identified differentially expressed and prognostic disulfidptosis genes. By conducting least absolute shrinkage and selection operator with multivariate Cox regression, four disulfidptosis genes were selected to create the prognostic signature. The implementation of the signature separated the training and validation cohorts into groups with high- and low-risk. Subsequently, the model w

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10784160 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature