Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive-compulsive disorder.

ABSTRACT:

Background

Neuroimaging studies have revealed the role of the right dorsolateral prefrontal cortex (DLPFC) in the neurobiological mechanism of obsessive-compulsive disorder (OCD). However, only a few studies have examined the functional connectivity (FC) pattern of the right DLPFC at rest in OCD.

Objective

The aim of this research is to examine the FC patterns of the right DLPFC at rest in OCD.

Methods

Twenty-eight medication-free patients with OCD and 20 healthy controls underwent resting-state functional magnetic resonance imaging. Seed-based FC and support vector machine (SVM) were used to analyze the imaging data.

Results

The patients with OCD showed reduced FC values in the right middle temporal gyrus (MTG), right superior temporal gyrus, right ventral ant

SUBMITTER: Zhong Z 

PROVIDER: S-EPMC10784187 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature