Assessment of the alpha 7 nicotinic acetylcholine receptor as an imaging marker of cardiac repair-associated processes using NS14490.

ABSTRACT:

Background

Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Noninvasive imaging using a radiotracer targeting these processes could be used to elucidate cardiac wound healing mechanisms. The alpha7 nicotinic acetylcholine receptor (ɑ7nAChR) stimulates pro-reparative macrophage activity and angiogenesis, making it a potential imaging biomarker in this context. We investigated this by assessing in vitro cellular expression of ɑ7nAChR, and by using a tritiated version of the PET radiotracer [¹⁸F]NS14490 in tissue autoradiography studies.

Results

ɑ7nAChR expression in human monocyte-derived macrophages and vascular cells showed the highest relative expressio

SUBMITTER: Reid VJM 

PROVIDER: S-EPMC10784260 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature