Balancing risks of recurrent venous thromboembolism and bleeding with extended anticoagulation: a decision analysis.

ABSTRACT:

Background

A decision to stop or continue anticoagulation after 3 months of anticoagulation for venous thromboembolism (VTE) should be made by weighing individual risks of recurrence and bleeding.

Objectives

To determine the optimal ratio of recurrence risk reduction to increase the risk of bleeding in terms of maximizing quality-adjusted life years (QALYs) gained.

Methods

Using a microsimulation model, outcomes within 5 years were simulated after assigning extended treatment if absolute recurrence risk reduction outweighed absolute increase in clinically relevant bleeding risk (International Society on Thrombosis and Haemostasis definition), weighted by a certain ratio. Data were simulated based on the Bleeding Risk Study, a prospective cohort including patients afte

SUBMITTER: de Winter MA 

PROVIDER: S-EPMC10784302 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature