A transcriptome based molecular classification scheme for cholangiocarcinoma and subtype-derived prognostic biomarker.

ABSTRACT: Previous studies on the molecular classification of cholangiocarcinoma (CCA) focused on certain anatomical sites, and disregarded tissue contamination biases in transcriptomic profiles. We aim to provide universal molecular classification scheme and prognostic biomarker of CCAs across anatomical locations. Comprehensive bioinformatics analysis is performed on transcriptomic data from 438 CCA cases across various anatomical locations. After excluding CCA tumors showing normal tissue expression patterns, we identify two universal molecular subtypes across anatomical subtypes, explore the molecular, clinical, and microenvironmental features of each class. Subsequently, a 30-gene classifier and a biomarker (called "CORE-37") are developed to predict the molecular subtype of CCA and prognosis,

SUBMITTER: Fan Z 

PROVIDER: S-EPMC10784309 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature