Magnetic resonance imaging of anal cancer: tumor characteristics and early prediction of treatment outcome.

ABSTRACT:

Purpose

To analyze tumor characteristics derived from pelvic magnetic resonance imaging (MRI) of patients with squamous cell carcinoma of the anus (SCCA) before and during chemoradiotherapy (CRT), and to compare the changes in these characteristics between scans of responders vs. nonresponders to CRT.

Methods

We included 52 patients with a pelvic 3T MRI scan prior to CRT (baseline scan); 39 of these patients received an additional scan during week 2 of CRT (second scan). Volume, diameter, extramural tumor depth (EMTD), and external anal sphincter infiltration (EASI) of the tumor were assessed. Mean, kurtosis, skewness, standard deviation (SD), and entropy values were extracted from apparent diffusion coefficient (ADC) histograms. The main outcome was locoregional treatment f

SUBMITTER: Hanekamp BA 

PROVIDER: S-EPMC10784345 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature