Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype.

ABSTRACT:

Introduction

Whether apolipoprotein E's (APOE's) involvement in lipid metabolism contributes to Alzheimer's disease (AD) risk remains unknown.

Methods

Incident probable dementia and cognitive impairment (probable dementia+mild cognitive impairment) were analyzed in relation to baseline serum lipids (total, low-density lipoprotein [LDL], high-density lipoprotein [HDL], non-HDL cholesterol, total-to-HDL, LDL-to-HDL, remnant cholesterol, and triglycerides) using Mendelian randomization in 5358 postmenopausal women from the Women's Health Initiative Memory Study. We also examined associations of baseline dietary cholesterol and fat with lipids based on APOE status.

Results

After an average of 11.13 years, less favorable lipid levels related to greater dementia and cogniti

SUBMITTER: Dunk MM 

PROVIDER: S-EPMC10784407 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature