Role of Sox9 in BPD and its effects on the Wnt/β-catenin pathway and AEC-II differentiation.
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ABSTRACT:
SUBMITTER: Wu D
PROVIDER: S-EPMC10784471 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
Role of Sox9 in BPD and its effects on the Wnt/β-catenin pathway and AEC-II differentiation.
Wu Di D Bai Dongqin D Yang Miao M Wu Bo B Xu Wei W
Cell death discovery 20240111 1
The excessive activation of the Wnt/β-catenin signaling pathway is an important regulatory mechanism that underlies the excessive proliferation and impaired differentiation of type 2 alveolar epithelial cells (AEC-II) in bronchopulmonary dysplasia (BPD). Sox9 has been shown to be an important repressor of the Wnt/β-catenin signaling pathway and plays an important regulatory role in various pathophysiological processes. We found that the increased expression of Sox9 in the early stages of BPD cou ...[more]
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