Immunological shifts during early-stage Parkinson's disease identified with DNA methylation data on longitudinally collected blood samples.

ABSTRACT: Parkinson's disease (PD) is the second most common neurodegenerative disease in the United States. Decades before motor symptoms manifest, non-motor symptoms such as hyposmia and rapid eye movement (REM) sleep behavior disorder are highly predictive of PD. Previous immune profiling studies have identified alterations to the proportions of immune cells in the blood of clinically defined PD patients. However, it remains unclear if these phenotypes manifest before the clinical diagnosis of PD. We utilized longitudinal DNA methylation (DNAm) microarray data from the Parkinson's Progression Marker's Initiative (PPMI) to perform immune profiling in clinically defined PD and prodromal PD patients (Prod). We identified previously reported changes in neutrophil, monocyte, and T cell numbers in PD p

SUBMITTER: Pike SC 

PROVIDER: S-EPMC10784484 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature