Gut microbial metabolites reveal diet-dependent metabolic changes induced by nicotine administration.

ABSTRACT: The gut microbiota has emerged as an important factor that potentially influences various physiological functions and pathophysiological processes such as obesity and type 2 diabetes mellitus. Accumulating evidence from human and animal studies suggests that gut microbial metabolites play a critical role as integral molecules in host-microbe interactions. Notably, several dietary environment-dependent fatty acid metabolites have been recognized as potent modulators of host metabolic homeostasis. More recently, nicotine, the primary active molecule in tobacco, has been shown to potentially affect host metabolism through alterations in the gut microbiota and its metabolites. However, the mechanisms underlying the interplay between host nutritional status, diet-derived microbial metabolites,

SUBMITTER: Ohue-Kitano R 

PROVIDER: S-EPMC10784489 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature