Semen microbiota are dramatically altered in men with abnormal sperm parameters.

ABSTRACT: There has recently been an explosion of studies implicating the human microbiome in playing a critical role in many disease and wellness states. The etiology of abnormal semen analysis (SA) parameters is not identified in 30% of cases; investigations involving the semen microbiome may bridge this gap. Here, we explore the relationship between the semen microbiome and alterations of sperm parameters. We recruited men presenting for fertility evaluation or vasectomy consultation with proven biological paternity. SA and next generation sequencing was performed. Differential abundance testing using Analysis of composition of Microbiota with Bias Correction (ANCOM-BC) was performed along with canonical correlational analysis for microbial community profiling. Men with abnormal (N = 27) sperm mo

SUBMITTER: Osadchiy V 

PROVIDER: S-EPMC10784508 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature