Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans.

ABSTRACT: Development of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship between androgens and genomic integrity determining human fertility. We used different study groups: individuals with Differences of Sex Development (DSD), including Complete Androgen Insensitivity Syndrome (CAIS) due to mutated androgen receptor (AR), and men with idiopathic nonobstructive azoospermia. Both showed genome integrity status influenced by androgen signaling via innate immune response activation in blood and gonads. Whole proteome analysis connected low AR to interleukin-specific gene expression, while compromised genome stability and tumorigenesis were also supported by interferons. AR expression was associated with predominant DNA d

SUBMITTER: Zimmer J 

PROVIDER: S-EPMC10784536 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature