Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8⁺ T-cells.

ABSTRACT: HIV remission can be achieved in some people, called post-treatment HIV controllers, after antiretroviral treatment discontinuation. Treatment initiation close to the time of infection was suggested to favor post-treatment control, but the circumstances and mechanisms leading to this outcome remain unclear. Here we evaluate the impact of early (week 4) vs. late (week 24 post-infection) treatment initiation in SIVmac₂₅₁-infected male cynomolgus macaques receiving 2 years of therapy before analytical treatment interruption. We show that early treatment strongly promotes post-treatment control, which is not related to a lower frequency of infected cells at treatment interruption. Rather, early treatment favors the development of long-term memory CD8⁺ T cells with enhance

SUBMITTER: Passaes C 

PROVIDER: S-EPMC10784587 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature