Clinical variables and genetic variants associated with perioperative anaphylaxis in Chinese Han population: A pilot study.

ABSTRACT:

Background

Perioperative anaphylaxis (POA) can lead to severe consequences. Identifying clinical risk factors and genetic loci associated with POA through pre-prescription screening may help reduce its incidence.

Methods

Using univariate regression and covariate-adjusted multivariate regression, we retrospectively analyzed the association between clinical characteristics and POA in 72 POA patients and 72 non-POA individuals. The discovery study of whole-exome association relied on whole-exome sequencing of 73 POA cases and 1339 healthy individuals. A replication study involving an independent set of 16 POA cases and 1339 healthy individuals confirmed this association. The accurate typing of human leucocyte antigen through exome sequencing (ATHLATES) algorithm and the whole-e

SUBMITTER: Qi Z 

PROVIDER: S-EPMC10784692 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature