Bacteria and viruses and clinical outcomes of asthma-bronchiectasis overlap syndrome: A cohort study.

ABSTRACT:

Background

Despite the high prevalence of co-existing bronchiectasis and asthma (asthma-bronchiectasis overlap syndrome [ABOS]), little is known regarding the dominant pathogens and clinical correlates.

Objective

To investigate the bacteria and viruses which differentially dominate in ABOS (including its subtypes) compared with bronchiectasis alone, and determine their relevance with bronchiectasis severity and exacerbations.

Methods

This was a prospective observational cohort study conducted between March 2017 and August 2023. We included 81 patients with ABOS and 107 patients with bronchiectasis alone. At steady-state baseline, patients underwent comprehensive assessments and sputum collection for bacterial culture and viral detection (quantitative polymerase-chain-

SUBMITTER: Zhang XX 

PROVIDER: S-EPMC10784706 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature