Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome.

ABSTRACT: The quality of oocytes in patients with polycystic ovary syndrome (PCOS) decreases, which is closely related to the function of oocytes' mitochondria. If mitochondrial dysfunction is involved in PCOS, it is likely to affect the function of cumulus cells. However, the mechanism of mitochondrial dysfunction remains unclear. In the present study, granulosa cells were collected from women attending the Hebei Reproductive Health Hospital and were divided into the normal ovarian reserve group (CON group) and the PCOS group. The mitochondrial ultrastructure was observed by transmission electron microscope, and the mitochondrial function was determined by detecting the ATP content, reactive oxygen species levels, the number of mitochondria and the mitochondrial membrane potential. Additionally, we

SUBMITTER: Xie C 

PROVIDER: S-EPMC10784735 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature