Diabetes mellitus and prostate cancer risk: A mendelian randomization analysis.

ABSTRACT:

Background

Some studies have directed towards an association between diabetes mellitus (DM) and prostate cancer (PCa); however, this specific relationship remains inconclusive. In recent years, Mendelian randomization (MR) has become a widely used analytical method for inferring epidemiological causes.

Aim

To investigated the potential relationship between DM and PCa using MR.

Methods

We downloaded relevant data on "diabetes" and "PCa" from the IEU OpenGWAS project database, performed three different methods to conduct MR, and carried out sensitivity analysis for verification.

Results

The results indicated that DM was an independent risk factor for PCa. The odds ratio (OR) values obtained using the inverse variance weighted method in this study were as follows:

SUBMITTER: Yuan JX 

PROVIDER: S-EPMC10784790 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature