Atorvastatin ameliorated myocardial fibrosis in db/db mice by inhibiting oxidative stress and modulating macrophage polarization.

ABSTRACT:

Background

People with diabetes mellitus (DM) suffer from multiple chronic complications due to sustained hyperglycemia, especially diabetic cardiomyopathy (DCM). Oxidative stress and inflammatory cells play crucial roles in the occurrence and progression of myocardial remodeling. Macrophages polarize to two distinct phenotypes: M1 and M2, and such plasticity in phenotypes provide macrophages various biological functions.

Aim

To investigate the effect of atorvastatin on cardiac function of DCM in db/db mice and its underlying mechanisms.

Methods

DCM mouse models were established and randomly divided into DM, atorvastatin, and metformin groups. C57BL/6 mice were used as the control. Cardiac function was evaluated by echocardiography. Hematoxylin and eosin and Masson st

SUBMITTER: Song XM 

PROVIDER: S-EPMC10784803 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature