Proteinuria screening and risk of bone fracture: a retrospective cohort study using a nationwide population-based database.

ABSTRACT:

Background and hypothesis

Proteinuria is associated with an increased risk of kidney function deterioration, cardiovascular disease, or cancer. Previous reports suggesting an association between kidney dysfunction and bone fracture may be confounded by concomitant proteinuria and were inconsistent regarding the association between proteinuria and bone fracture. Therefore, we aimed to evaluate the association using a large administrative claims database in Japan.

Methods

Using the DeSC database, we retrospectively identified individuals with laboratory data including urine dipstick test between August 2014 and February 2021. We evaluated the association between proteinuria and vertebral or hip fracture using multivariable Cox regression analyses adjusted for various backgroun

SUBMITTER: Okada A 

PROVIDER: S-EPMC10784970 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature