Circulating exosomal microRNAs as biomarkers of lupus nephritis.

ABSTRACT:

Objective

Disruption in the delicate symphony of genes, microRNA (miRNA), or protein expression can result in the dysregulation of the immune system, leading to the devastating consequences such as lupus nephritis (LN). The capacity of exosomes to transport miRNAs between cells and modify the phenotype of recipient cells implies their involvement in persistent kidney inflammation. This study unveils identifying two previously undiscovered exosomal miRNAs in the serum of LN patients, offering potential solutions to the current challenges in LN diagnosis and management.

Methods

Initially, we used a reagent-based kit to isolate serum exosomes from patients with Systemic lupus erythematosus (SLE) and used Trizol method for total RNA extraction. Subsequently, we employed small RN

SUBMITTER: Chen F 

PROVIDER: S-EPMC10785001 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature