The preliminary evidence on the association of the gut microbiota with stroke risk stratification in South Chinese population.

ABSTRACT:

Aims

This study aimed to investigate the association between the gut microbiota and the risk of stroke.

Methods

Faecal samples from 60 participants in South China, including 45 individuals with risk factors for stroke and 15 healthy controls, were collected and subjected to 16S rRNA sequencing. A bioinformatics analysis was performed to characterise the gut microbial diversity and taxonomic compositions at different risk levels (low, moderate, and high) of stroke. Functional prediction and correlation analyses between the microbiota and laboratory markers were performed to explore the potential mechanisms.

Results

A significant difference in beta diversity was observed between the participants from the stroke risk and healthy control groups. Linear discriminant effect

SUBMITTER: Huang H 

PROVIDER: S-EPMC10785002 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature