Polymorphisms in CLEC5A and CLEC7A genes modify risk for inflammatory bowel disease.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) seems to arise from an interplay between genetic and environmental factors. CLEC5A and CLEC7A genes code for 2 members of the C-type lectin receptor superfamily, which participate in the immune response against various pathogens, mediating inflammatory signaling. CLEC5A polymorphisms have been linked to the risk of Crohn's disease (CD), whereas CLEC7A has been implicated in fungal dysbiosis, chemically induced colitis in mice and undertreated ulcerative colitis (UC) in humans. This study aimed to explore how specific CLEC5A and CLEC7A polymorphisms contribute to the development of CD and UC.

Methods

One hundred twelve CD patients, 94 UC patients and 164 sex- and age- matched healthy individ

SUBMITTER: Legaki E 

PROVIDER: S-EPMC10785015 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature