Development of ¹⁸F-Labeled hydrophilic <i>trans</i>-cyclooctene as a bioorthogonal tool for PET probe construction.

ABSTRACT: We report the development of a hydrophilic ¹⁸F-labeled a-TCO derivative [¹⁸F]3 (log P = 0.28) through a readily available precursor and a single-step radiofluorination reaction (RCY up to 52%). We demonstrated that [¹⁸F]3 can be used to construct not only multiple small molecule/peptide-based PET agents, but protein/diabody-based imaging probes in parallel.

SUBMITTER: Xu M 

PROVIDER: S-EPMC10785124 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature