Cognition and motion dysfunction-associated brain functional network disruption in diabetic peripheral neuropathy.

ABSTRACT: Neuroimaging studies have demonstrated extensive brain functional alterations in cognitive and motor functional areas in Type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN), suggesting potential alterations in large-scale brain networks related to DPN and associated cognition and motor dysfunction. In this study, using resting-state functional connectivity (FC) and graph theory computational approaches, we investigated the topological disruptions of brain functional networks in 28 DPN, 43 T2DM without DPN (NDPN), and 32 healthy controls (HCs) and examined the correlations between altered network topological metrics and cognitive/motor function parameters in T2DM. For global topology, NDPN exhibited a significantly decreased shortest path length compared with HCs, sugg

SUBMITTER: Xin H 

PROVIDER: S-EPMC10785193 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature