Isoniazid Monoresistance and Antituberculosis Treatment Outcome in Persons With Pulmonary Tuberculosis in Brazil.

ABSTRACT:

Background

The high burden of drug-resistant tuberculosis (TB) is a problem to achieve the goals of the End TB Strategy by 2035. Whether isoniazid monoresistance (Hr) affects anti-TB treatment (ATT) outcomes remains unknown in high-burden countries.

Methods

We evaluated determinants of ATT outcome among pulmonary TB cases reported to the National Notifiable Disease Information System (SINAN) between June 2015 and June 2019, according to drug sensitivity testing (DST) results. Binomial logistic regression models were employed to evaluate whether Hr was associated with an unfavorable ATT outcome: death or failure, compared to cure or treatment completion.

Results

Among 60 804 TB cases reported in SINAN, 21 197 (34.9%) were included in the study. In this database, the fr

SUBMITTER: Araujo-Pereira M 

PROVIDER: S-EPMC10785213 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature