Long-Term Stability of Cord Blood Units After 29 Years of Cryopreservation: Follow-Up Data From the Jose Carreras Cord Blood Bank.

ABSTRACT: The José Carreras Cord Blood Bank (CBB) located in Düsseldorf as of today stores 21 215 active cryopreserved cord blood units (CBUs) applicable as a source for hematopoietic stem cell (HSC) transplantation. Since the success of transplantation outcomes is mainly dependent on the cord blood quality, typical parameters are evaluated by a Stability Monitoring Program specified by the FACT Standards. The longest expiration time determined to date is 29 years for unseparated units, 25 years for manual and 18 years for automated volume-reduced units licensed by the Paul-Ehrlich Institute. According to the CBB stability program TNC count, TNC recovery, TNC viability, CD34+7AAD- viability, CD45+7AAD- viability and CFC count were determined for all 3 processing methods applied over time. As a measu

SUBMITTER: Liedtke S 

PROVIDER: S-EPMC10785215 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature