Decalepis hamiltonii root fraction alleviates CCl₄ hepatotoxicity in a rat model.

ABSTRACT:

Background

Decalepis hamiltonii (D. hamiltonii) is Indian folk medicine in herbal preparations, to reduce appetite, and cures dysentery, bronchitis, uterine hemorrhage, and other ailments.

Objective

The current investigation focused on the hepatoprotective effect of D. hamiltonii roots fractions against liver damage.

Materials and methods

The current research discussed the fraction from D. hamiltonii root extracts was used. Male Wistar rats (albino strain) were grouped into 4 distinct groups of six animals each. Group I: plain water and vehicle whereas Group II (CCl₄ control): CCl₄ (1 ml/kg, 20 % v/v in olive oil) over 7 days and vehicle; Over 7 days, Group III received Silymarin 100 mg/kg/day and tap water with 20 % v/v of CCl₄, where

SUBMITTER: Labhade S 

PROVIDER: S-EPMC10785264 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature