α-Glucosidase Inhibitory Activity and Cytotoxicity of CeO₂ Nanoparticles Fabricated Using a Mixture of Different Cerium Precursors.

ABSTRACT: A mixture of three distinct cerium precursors (Ce(NO₃)₃·6H₂O, CeCl₃·7H₂O, and Ce(CH₃COO)₃·H₂O) was used to prepare cerium oxide nanoparticles (CeO₂ NPs) in a polyol-mediated synthesis. Different ratios of diethylene glycol (DEG) and H₂O were utilized in the synthesis. The properties of the synthesized CeO₂ NPs, such as structural and morphological properties, were investigated to observe the effect of the mixed cerium precursors. Crystallite sizes of 7-8 nm were obtained for all samples, and all synthesized samples were confirmed to be in the cubic phase. The average particle sizes of the spherical CeO₂ were between 9 and 13 nm. The successful synthesis of CeO₂ can also be confirmed via the vibrational band of Ce-O from the FTIR. Antidiabetic properties of the synthesized CeO₂ NPs were investigated using α-glucosidase enzyme inhibition assay, and the concentration of the synthesized CeO₂ NPs was varied in the study. The biocompatibility properties of the synthesized CeO₂ NPs were investigated via cytotoxicity tests, and it was found that all synthesized materials showed no cytotoxic properties at lower concentrations (62.5-125 μg/mL).

SUBMITTER: Matussin SN 

PROVIDER: S-EPMC10785273 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature