Exploring the relationship between metabolism and immune microenvironment in osteosarcoma based on metabolic pathways.

ABSTRACT:

Background

Metabolic remodeling and changes in tumor immune microenvironment (TIME) in osteosarcoma are important factors affecting prognosis and treatment. However, the relationship between metabolism and TIME needs to be further explored.

Methods

RNA-Seq data and clinical information of 84 patients with osteosarcoma from the TARGET database and an independent cohort from the GEO database were included in this study. The activity of seven metabolic super-pathways and immune infiltration levels were inferred in osteosarcoma patients. Metabolism-related genes (MRGs) were identified and different metabolic clusters and MRG-related gene clusters were identified using unsupervised clustering. Then the TIME differences between the different clusters were compared. In addition, an

SUBMITTER: Wu C 

PROVIDER: S-EPMC10785352 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature