Robustness evaluations of pathway activity inference methods on gene expression data.

ABSTRACT:

Background

With the exponential growth of high-throughput technologies, multiple pathway analysis methods have been proposed to estimate pathway activities from gene expression profiles. These pathway activity inference methods can be divided into two main categories: non-Topology-Based (non-TB) and Pathway Topology-Based (PTB) methods. Although some review and survey articles discussed the topic from different aspects, there is a lack of systematic assessment and comparisons on the robustness of these approaches.

Results

Thus, this study presents comprehensive robustness evaluations of seven widely used pathway activity inference methods using six cancer datasets based on two assessments. The first assessment seeks to investigate the robustness of pathway activity in pathwa

SUBMITTER: Hui TX 

PROVIDER: S-EPMC10785356 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature