Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [¹⁸F]PSS232 PET/MRI study.

ABSTRACT:

Background

Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the initial pathophysiological mechanism of Alzheimer's disease (AD). The study aims to investigate the association between mGluR5 availability and AD's biomarkers and cognitive function.

Methods

We examined 35 individuals with mGluR5 tracer [¹⁸F]PSS232 to assess mGluR5 availability, and with [¹⁸F]Florbetapir PET to assess global amyloid deposition, and [¹⁸F]FDG PET to assess glucose metabolism. The plasma neurofilament light (NfL) and p-tau181 levels in a subset of individuals were measured (n = 27). The difference in mGluR5 availabilit

SUBMITTER: Wang J 

PROVIDER: S-EPMC10785459 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature