Driving pressure of respiratory system and lung stress in mechanically ventilated patients with active breathing.

ABSTRACT:

Background

During control mechanical ventilation (CMV), the driving pressure of the respiratory system (ΔP_rs) serves as a surrogate of transpulmonary driving pressure (ΔP_lung). Expiratory muscle activity that decreases end-expiratory lung volume may impair the validity of ΔP_rs to reflect ΔP_lung. This prospective observational study in patients with acute respiratory distress syndrome (ARDS) ventilated with proportional assist ventilation (PAV+), aimed to investigate: (1) the prevalence of elevated ΔP_lung, (2) the ΔP_rs-ΔP_lung relationship, and (3) whether dynamic transpulmonary pressure (Plung_sw) and effort indices (transdiaphragmatic and respiratory muscle pressure swings) remain within safe lim

SUBMITTER: Stamatopoulou V 

PROVIDER: S-EPMC10785492 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature