The level of partial pressure of carbon dioxide affects respiratory effort in COVID-19 patients undergoing pressure support ventilation with extracorporeal membrane oxygenation.

ABSTRACT:

Background

Patients with COVID-19 undergoing pressure support ventilation (PSV) with extracorporeal membrane oxygenation (ECMO) commonly had high respiratory drive, which could cause self-inflicted lung injury. The aim of this study was to evaluate the influence of different levels of partial pressure of carbon dioxide(PaCO₂) on respiratory effort in COVID-19 patients undergoing PSV with ECMO.

Methods

ECMO gas flow was downregulated from baseline (respiratory rate < 25 bpm, peak airway pressure < 25 cm H₂O, tidal volume < 6 mL/kg, PaCO₂ < 40 mmHg) until PaCO₂ increased by 5 - 10 mmHg. The pressure muscle index (PMI) and airway pressure swing during occlusion (ΔPOCC) were used to monitor respiratory effort, and they were measured be

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC10785506 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature