A study of genetic variants associated with skin traits in the Vietnamese population.

ABSTRACT:

Background

Most skin-related traits have been studied in Caucasian genetic backgrounds. A comprehensive study on skin-associated genetic effects on underrepresented populations such as Vietnam is needed to fill the gaps in the field.

Objectives

We aimed to develop a computational pipeline to predict the effect of genetic factors on skin traits using public data (GWAS catalogs and whole-genome sequencing (WGS) data from the 1000 Genomes Project-1KGP) and in-house Vietnamese data (WGS and genotyping by SNP array). Also, we compared the genetic predispositions of 25 skin-related traits of Vietnamese population to others to acquire population-specific insights regarding skin health.

Methods

Vietnamese cohorts of whole-genome sequencing (WGS) of 1008 healthy individuals fo

SUBMITTER: Hoang TH 

PROVIDER: S-EPMC10785522 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature