Tafamidis improves myocardial longitudinal strain in A97S transthyretin cardiac amyloidosis.

ABSTRACT:

Background

Transthyretin cardiomyopathy (ATTR-CM) is a debilitating disease that has received much attention since the emergence of novel treatments. The Transthyretin Cardiomyopathy Clinical Trial showed that tafamidis, a transthyretin tetramer stabilizer, effectively reduced the declines in functional capacity and quality of life. However, Ala97Ser (A97S) hereditary ATTR-CM is underrepresented in major ATTR-CM tafamidis trials.

Objectives

We aim to investigate the change in global longitudinal strain (GLS) of A97S ATTR-CM patients after 12 months of tafamidis treatment.

Methods

We retrospectively analysed a prospective cohort of patients with A97S ATTR-CM who received tafamidis meglumine (61 mg/day) at the National Taiwan University Hospital. Echocardiography with s

SUBMITTER: Wu YA 

PROVIDER: S-EPMC10785723 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature