Hydrolysis of Antimicrobial Peptides by Extracellular Peptidases in Wastewater.

ABSTRACT: Several antimicrobial peptides (AMPs) are emerging as promising novel antibiotics. When released into wastewater streams after use, AMPs might be hydrolyzed and inactivated by wastewater peptidases─resulting in a reduced release of active antimicrobials into wastewater-receiving environments. A key step towards a better understanding of the fate of AMPs in wastewater systems is to investigate the activity and specificity of wastewater peptidases. Here, we quantified peptidase activity in extracellular extracts from different stages throughout the wastewater treatment process. For all four tested municipal wastewater treatment plants, we detected highest activity in raw wastewater. Complementarily, we assessed the potential of enzymes in raw wastewater extracts to biotransform 10 selected A

SUBMITTER: Wichmann N 

PROVIDER: S-EPMC10785756 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature