A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer.

ABSTRACT: Racial disparities between Black/African Americans (AA) and White patients in colorectal cancer are an ever-growing area of concern. Black/AA show the highest incidence and have the highest mortality among major U.S. racial groups. There is no definite cause other than possible sociodemographic, socioeconomic, education, nutrition, delivery of healthcare, screening, and cultural factors. A primary limitation in this field is the lack of and small sample size of Black/AA studies. Thus, this study aimed to investigate whether differences in gene expression contribute to this ongoing unanswered racial disparity issue. In this study, we examined transcriptomic data of Black/AA and White patient cohorts using a bioinformatic and systems biology approach. We performed a Kaplan-Meier overall surv

SUBMITTER: Nwaokorie A 

PROVIDER: S-EPMC10785768 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature